Kazuya Yamagata Selected Research

Type 1 Maturity-Onset Diabetes of the Young

1/2017	Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
12/2008	A common P2 promoter polymorphism of the hepatocyte nuclear factor-4alpha gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.
1/2008	Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
2/2006	Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
4/2005	Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.
4/2002	Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha.

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Kazuya Yamagata Research Topics

Disease

15	Type 2 Diabetes Mellitus (MODY) 10/2021 - 02/2005
11	Mason-Type Diabetes 01/2017 - 01/2002
6	Type 1 Maturity-Onset Diabetes of the Young 01/2017 - 04/2002
5	Neoplasms (Cancer) 11/2021 - 10/2003
4	Obesity 10/2020 - 04/2002
4	Hypoxia (Hypoxemia) 01/2017 - 04/2011
3	Type 3 Maturity-Onset Diabetes of the Young 09/2014 - 06/2002
2	Insulin Resistance 10/2020 - 03/2005
2	Fatty Liver 01/2017 - 04/2014
2	Glucose Intolerance 05/2015 - 04/2014
2	Hyperglycemia 12/2005 - 01/2002
1	Hypoglycemia (Reactive Hypoglycemia) 11/2020
1	Cardiomegaly (Heart Hypertrophy) 01/2020
1	Acute Kidney Injury (Acute Renal Failure) 12/2018
1	Cartilage Diseases (Cartilage Disease) 02/2018
1	Osteoarthritis 02/2018
1	Muscular Atrophy (Muscle Atrophy) 01/2018
1	Carcinogenesis 01/2018
1	Inflammation (Inflammations) 01/2018
1	Sarcopenia 01/2018
1	Metabolic Diseases (Metabolic Disease) 01/2018
1	Atherosclerotic Plaque (Atheroma) 01/2018
1	Fibrosis (Cirrhosis) 09/2015
1	Diabetes Mellitus 01/2014
1	Amyloidosis 08/2012
1	Hypertrophy 09/2011
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2011
1	Glucagonoma 01/2009
1	Hypertension (High Blood Pressure) 11/2008
1	Cysts 05/2007
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 05/2007
1	Insulinoma 12/2005
1	Hyperplasia 05/2004
1	Hyperinsulinism (Hyperinsulinemia) 05/2004
1	Carcinoid Tumor (Carcinoid) 10/2003
1	Cushing Syndrome 10/2003
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2002

Drug/Important Bio-Agent (IBA)

10	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 01/2002
8	Hepatocyte Nuclear FactorsIBA 01/2017 - 01/2002
6	SirtuinsIBA 11/2021 - 01/2018
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 03/2005
4	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA 01/2008 - 06/2002
3	Glucagon (Glukagon)FDA Link 11/2020 - 01/2009
3	Insulin (Novolin)FDA Link 10/2020 - 04/2002
2	Transcription Factors (Transcription Factor)IBA 10/2021 - 01/2008
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 02/2011
2	Oxygen (Dioxygen)IBA 06/2015 - 03/2005
2	Hepatocyte Nuclear Factor 1-betaIBA 01/2008 - 05/2007
1	AntibodiesIBA 11/2021
1	Lanthanoid Series Elements (Lanthanides)IBA 11/2021
1	Receptor Tyrosine Kinase-like Orphan ReceptorsIBA 11/2021
1	EuropiumIBA 11/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2021
1	ThiazolidinedionesIBA 10/2021
1	LigandsIBA 10/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2020
1	Nonesterified Fatty Acids (NEFA)IBA 10/2020
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2020
1	Nicotinamide MononucleotideIBA 01/2020
1	Cisplatin (Platino)FDA LinkGeneric 12/2018
1	NAD (NADH)IBA 01/2018
1	ApolipoproteinsIBA 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017
1	AMP-Activated Protein KinasesIBA 01/2017
1	Phosphotransferases (Kinase)IBA 01/2017
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2017
1	Proteasome InhibitorsIBA 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 01/2017
1	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2015
1	Small Interfering RNA (siRNA)IBA 09/2015
1	GlucokinaseIBA 05/2015
1	Liver GlycogenIBA 05/2015
1	Nonsense Codon (Nonsense Mutation)IBA 09/2014
1	C-Reactive ProteinIBA 09/2014
1	Biomarkers (Surrogate Marker)IBA 09/2014
1	Triglycerides (Triacylglycerol)IBA 04/2014
1	Islet Amyloid PolypeptideIBA 08/2012
1	Lys Transfer RNAIBA 09/2011
1	pimonidazoleIBA 04/2011
1	phosphatidylcholine-ceramide phosphocholine transferaseIBA 02/2011
1	IncretinsIBA 03/2010
1	CalciumIBA 01/2009
1	AldosteroneIBA 11/2008
1	SaltsIBA 11/2008
1	SodiumIBA 11/2008
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2008
1	Mutant Proteins (Protein, Mutant)IBA 11/2008
1	Nicotinamide PhosphoribosyltransferaseIBA 03/2008
1	Messenger RNA (mRNA)IBA 05/2007
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 07/2005
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 03/2005
1	Molecular Chaperones (Chaperone, Molecular)IBA 03/2005
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 05/2004
1	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2003
1	Adrenocorticotropic Hormone (ACTH)FDA Link 10/2003
1	AdiponectinIBA 09/2002

Therapy/Procedure

2	Glycemic Control 01/2013 - 09/2011
1	Therapeutics 12/2018
1	Resistance Training 01/2018
1	Denervation 01/2018